Harzianic acid: a novel siderophore fromTrichoderma harzianum
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منابع مشابه
Harzianic acid: a novel siderophore from Trichoderma harzianum.
Agriculture-relevant microorganisms are considered to produce secondary metabolites during processes of competition with other micro- and macro-organisms, symbiosis, parasitism or pathogenesis. Many different strains of the genus Trichoderma, in addition to a direct activity against phytopathogens, are well-known producers of secondary metabolites and compounds that substantially affect the met...
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The dual culture of Trichoderma harzianum and Catharanthus roseus callus produced an antimicrobial compound with a remarkable activity against the Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis. Structural elucidation revealed that this compound, which we have named trichosetin, is a novel tetramic acid (2,4-pyrrolidinedione) antibiotic and a homolog of the fungal metabolite...
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Serine/threonine phosphatase type 2A (PP2A) is an intracellular protein phosphatase, which catalyzes dephosphorylation of many substrates. We have recently found that specific inhibitors of PP2A augment natural killer cells in vivo and inhibit tumor metastasis1-3). Thus, a specific inhibitor of PP2A is a candidate for a new immune activator. In the course of our searching for a novel PP2A inhib...
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A specific enzymatic method to determine the amounts of itoic acid, a Bacillus subtilis siderophore, and 2,3-dihydroxybenzoic acid (2,3-DHBA) was devised. A sample was incubated first with hippurate hydrolase and then with 2,3-DHBA-3,4-dioxygenase. Itoic acid was estimated from the increase in A374. The incubation with the first enzyme was omitted for the determination of 2,3-DHBA.
متن کاملTotal synthesis and biological evaluation of the tetramic acid based natural product harzianic acid and its stereoisomers.
The bioactive natural product harzianic acid was prepared for the first time in just six steps (longest linear sequence) with an overall yield of 22%. The identification of conditions to telescope amide bond formation and a Lacey-Dieckmann reaction into one pot proved important. The three stereoisomers of harzianic acid were also prepared, providing material for comparison of their biological a...
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ژورنال
عنوان ژورنال: FEMS Microbiology Letters
سال: 2013
ISSN: 0378-1097
DOI: 10.1111/1574-6968.12231